GLYPHSATE – a possible substitut?
Unusual sugar from cyanobacteria acts as natural herbicide:
Chemists and microbiologists at the University of Tübingen have discovered a sugar molecule that inhibits plants and microorganisms and is harmless to human cells – an possible alternative to the controversial glyphosate?
This natural substance could compete with the controversial herbicide glyphosate: The newly found sugar molecule from cyanobacteria inhibits the growth of various microorganisms and plants, but is harmless to humans and animals. The joint study was conducted by Dr. med. Klaus Brilisauer, Professor Stephanie Grond (Institute of Organic Chemistry) and Professor Karl Forchhammer (Interfaculty Institute for Microbiology and Infection Medicine). It was published on Friday in Nature Communications.
Substances for pharmaceutical or agricultural are often of natural origin. These can consist of complex or relatively simple chemical structures. Often, the genius of such substances lies in their simplicity: so-called "antimetabolites" interact with vital processes in the cell by mimicking metabolic products. The result is a disruption of the biological process, which can lead to growth inhibition or even the death of the affected cell.
The Tübingen chemistry and microbiology research team came across a very unusual antimetabolite with a strikingly simple chemical structure: a sugar molecule scientifically called "7-deoxy-sedoheptulose" (7dSh). Unlike ordinary carbohydrates, which usually act as an energy source for growth, this substance inhibits the growth of various plants and microorganisms, such as bacteria and yeasts. The sugar blocks an enzyme of the so-called shikimate pathway, a metabolic pathway that exists only in microorganisms and plants. For this reason, the scientists classify the substance as harmless to humans and animals and have already confirmed this in preliminary studies.
The long-term goal is to replace controversial herbicides and their dangerous by-products, the researchers say. The effectiveness of 7dSh on the fields, its biodegradability and harmlessness towards livestock and humans needs further investigation in comprehensive long-term studies.
Klaus Brilisauer, Johanna Rapp, Pascal Rath, Anna Schoellhorn, Lisa Bleul, Elisabeth Weiss, Mark Stahl, Stephanie Grond, Karl Forchhammer "Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms"
Published in Nature Communications (February 1st, 2019). DOI: 10.1038 / s41467-019-08476-8
From: Sonnenseiten news, 16.2.2019
Source University of Tübingen 2019